新書推薦：
《
日债、负利率与流动性陷阱（经济下行期，我们如何自救？国内日本问题重要研究专家方明教授重磅作品）
》
售價：HK$
151.8
《
马太效应
》
售價：HK$
54.8
《
新美术馆学（第3辑）
》
售價：HK$
97.9
《
海派文化地理
》
售價：HK$
107.8
《
中国画颜色的研究（修订版）
》
售價：HK$
54.9
《
日本突围：平成三十年日本企业的挣扎、破局与重生
》
售價：HK$
96.8
《
中国精怪图鉴 阿亮著 精怪是古人对抗未知的隐喻 读它们的故事学会与内心的恐惧共处 一本书带你邂逅千年
》
售價：HK$
97.9
《
大唐之美（梦回唐朝的导览手册，考古、艺术、历史、文学融为一体，全景视角，640幅全彩图片，带你踏上唐
》
售價：HK$
173.8
|
| 編輯推薦： |
1．本书为英文专著，为开发中国的传统药物带来更大的发展空间。
2.本书可以成为中药学或生物学相关专业教材用书。
3.本书研究水平水平较高，已发表高水平的SCI论文6篇，并深受同行专家的高度赞扬。
4. 本书出版将会进一步拓展Ampelopsin在临床的应用范围，为炎性疾病、神经退行性疾病及肿瘤疾病的联合治疗提供理论依据。
|
| 內容簡介： |
蛇葡萄素（Ampelopsin）又名双氢杨梅素（dihydromyricetin，DMY）是藤茶中一种重要的黄酮类物质。研究表明，Ampelopsin具有广泛的生物学功能：抗炎、抗氧化、抗肿瘤、保肝、改善运动疲劳等。
來源：香港大書城megBookStore,http://www.megbook.com.hk
本书首从Ampelopsin的结构入手，然后分章节来探讨Ampelopsin的抗炎、抗氧化、抗肿瘤、保肝、神经保护、改善运动疲劳及衰老性肌萎缩的作用；阐明Ampelopsin发挥上述作用的信号分子或者靶标；Ampelopsin发展成为功能性食品的前景。
|
| 關於作者： |
|
寇现娟，女，副教授。健康科学学院运动医学教研室教师。郑州大学医学院生物化学与分子生物学专业硕士，华中科技大学同济医学院生物化学与分子生物学专业博士。
|
| 目錄：
|
The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSmediated
activation of PI3KAktNFB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2ARE pathway23
Chapter 4Antitumor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2induced apoptosis by ERK and Akt signaling
pathways and upregulation of heme oxygenase159
5.2Ampelopsin attenuates 6OHDAinduced neurotoxicity by regulating
GSK3NRF2ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimers disease80
6.3Ampelopsin attenuates brain aging of Dgalinduced rats through miR34amediated SIRT1mTOR signaling pathway89
6.4Swimming attenuates Dgalactoseinduced brain aging via suppressing miR34amediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130amediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNAregulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates Dgalinduced oxidative stressrelated skeletal muscle atrophy through activating AMPKSIRT1PGC1 signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156
|
| 內容試閱：
|
Ampelopsis grossedentata is widely distributed in the South of China.Its tender stems and leaves are exploited in China to prepare a health beverage named as Rattan tea.Ampelopsin is one of the most important flavonoids found in Rattan tea.As a dihydromyricetin DHM，ampelopsin was first isolated from Ampelopsis meliaefolia by Kotake and Kubota in 1940，and was reported as a major bioactive component in Ampelopsis grossedentata later.Nowadays，ampelopsin，as a major bioactive component in Rattan tea，has a broad range of biological functions.During the past decade，the bioactivity of ampelopsin in Rattan tea has gained extensive attention and increasing scientific investigations related to its pharmacological functions and underlying mechanisms have been reported.Herein，the current research progress in the pharmacological functions and corresponding action mechanisms as well as potential benefits in chronic diseases have been summarized.This study will start a series of studies of ampelopsin from the following aspects：antiinflammatory，antioxidative，antitumor and neuroprotective effects，and alleviate brain aging and sarcopenia.We mainly focus the effect and molecular mechanism of ampelopsin on inflammation，tumor and neuroprotective effects in different cells and animal models.
Many intervention strategies have been investigated in order to understand their ability for slowing down the aging process of brain and skeletal muscle，and exercise training has been confirmed to inhibit oxidative stress and apoptotic signaling，thus effectively executing neuroprotection and sarcopenia.Aerobic exercise，such as running，has been proven to be a very effective way to improve adult hippocampal neurogenesis and learning.Some reports have also shown that treadmill and voluntary wheel running can improve behavioral performance and accelerate mitochondrial fitness of brain by reducing oxidative damage，rescuing abnormal mitochondrial dynamics，and inhibiting excessive apoptotic signaling.
|
|
購物車/收銀台(0) | 在線留言板
| 付款方式
| 運費計算
| 聯絡我們
| 幫助中心 |
加入書簽
HOME
新書上架
暢銷書架
